Dr. Roger Biringer (COM-Bradenton)
Dr. Roger Biringer is a Professor of Biochemistry at LECOM-Bradenton. He earned his Ph.D. from the University of California, Santa Cruz in Biochemistry and Biophysics in 1985, his M.Sc. from San Jose State University in Chemistry in 1979, and his B.A. from the University of California, Santa Cruz in Biology and Chemistry in 1975.
Current research involves examining the hypothesis that dysregulation of brain Na+/K+ ATPase (NKA) pumps primes migraineurs for their headaches. We have developed a robust NKA assay protocol are currently characterizing the regulation of NKA by various ouabain-like compounds (OLCs) that are known to regulate NKA pumping.
Current and Future Projects
- In collaboration with the California Institute of Technology and Huntington Medical Research Institutes, we plan to evaluate the efficacy of synthetic OLC compounds as NKA inhibitors for potential as pharmaceuticals for migraine mitigation and prevention.
- Develop a miniaturized version of our current assay to a 96 well plate format to allow for rapid evaluation of efficacy of large numbers of synthetic migraine pharmaceuticals.
- Determine the efficacy of NKA regulation by endocannabinoids that are known to be involved in migraine pathology.
- Develop a modified assay for application to NKA derived from tissue.
Biringer RG. Migraine signaling pathways: amino acid metabolites that regulate migraine and predispose migraineurs to headache. Mol Cell Biochem. 2022 Apr 28. https://doi:10.1007/s11010-022-04438-9
Biringer RG (2021) A review of non-prostanoid, eicosanoid receptors: expression, characterization, regulation, and mechanism of action. J Cell Commun Signal15(2):155-184. https://doi:10.1007/s12079-020-00585-0
Biringer, RG (2021) The Rise and Fall of Anandamide: Processes that Control Synthesis, Degradation and Storage. Mol Cell Biochem 476(7):2753-2775. https://doi:10.1007/s11010-021-04121-5
Biringer, RG (2021) A Review of Prostanoid Receptors: Expression, Characterization, Regulation, and Mechanism of Action. J Cell Commun Signal 15(2), 155-184. https://doi.org/10.1007/s12079-020-00585-0
Biringer, RG (2021) Endocannabinoid signaling pathways: beyond CB1R and CB2R. J Cell Commun Signal. 15(3):335-360. https://doi.org/10.1007/s12079-021-00622-6
Google Scholar-indexed Publications