Rocco J. Rotello, Ph.D.

Dr. Rotello is Associate Professor of Pharmacology. He is a cell and molecular biologist trained in experimental pathology, University of Colorado,16 years of drug discovery research (Procter & Gamble Pharmaceuticals) focused on human antibody development. Served as consultant with companies while teaching and performing research at Cedarville University School of Pharmacy.  Recent industry role was in a sterile drug manufacturing 503b, cGMP facility, focused on testing sterile compounded aseptically filled syringes and IV bags (STAQ Pharma LLC of Ohio).  Other areas of research include drug formulation, OTC supplements, combination drug/devices focused on novel ways to deliver supplements orally for energy and health.

Current Research Interests

Endothelial cell survival by targeting PTP Beta Tyrosine phosphatase.

Antibodies that Bind Human Protein Tyrosine Phosphatase (HPTPBeta) and Uses Thereof.

Interplay between endothelial cell hypoxia, hemoglobin fragments and phosphatase activation.

Humanized antibody activity to single transmembrane phosphatases, PTP Beta and activity of intact IgG antibody framework and Fab antibody fragments.

Ongoing Research Projects

Autism spectrum disorder, underlying factors contributing to disorder, family, diet, culture and exposures to various agents in the environment.

Energy/health using novel deliver of paraxanthine, cognizin (citicoline), in liquid and powder liposomal formats.

Poly ADP ribose formulation for eye and skin injury, salvage tissues from injury and chemical exposure, that impacts DNA.

Normal programmed cell death in frogs before, during and after emergence from winter freeze.

Recent Articles Published

Rotello RJ, Lawhead JG, Injeti ER, Veenstra TD (2022). Unique COVID/Anti-Spike Protein Immune Responses in Two Elderly Patients without COVID-19 Vaccination. Microbiology, Immunology and Pathology Research Open, 3 (1):1-3.

Link:

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Rotello RJ,  Veenstra TD (2021). Mass Spectrometry Techniques: Principles and Practices for Quantitative Proteomics. Current protein & Peptide Science, 22(2):121–133. https://doi.org/10.2174/1389203721666200921153513