Mission & Goals
The goals of the Laboratory of Experimental Myology and Osteopathic Research at Lecom
are twofold: The first aspect of our research assesses the effects of nerve damage (axotomy
and compression) on muscle function, biochemistry and morphology. This approach uses the rat
sciatic nerve model, and has gone on to assess the possible ameliorative effects of
antioxidant, exercise and osteopathic manipulative therapies.
The second facet of our lab's research is focused on understanding the effect
of the intracellular milieu on the contractile force and calcium-sensitivity and other
functional parameters of striated muscle (both skeletal and cardiac). More specifically, the
goal is to understand the mechanism(s) involved in the alteration of contractility by fatigue
metabolites such as inorganic phosphate (Pi) and hydrogen ions (H+), both of which decrease
force generation and calcium-sensitivity of striated muscle.