The Institutional Animal Care and Use Committee (IACUC) is a self-regulating entity that,
according to U.S. federal law, must be established by institutions that use laboratory animals for
research or instructional purposes to oversee and evaluate all aspects of an institution's animal
care and use program. LECOM employees who conduct research involving the use of laboratory animals
must submit an IACUC Application to obtain permission to conduct research using laboratory
IACUC Form Instructions
Type the name of the Principal Investigator in the Header portion of the first page in the space
after “Principal Investigator:”
DO NOT type anything in the space for IACUC APPLICATION #. This is assigned by the IACUC
Fill out the requested information (name, department, project title, phone numbers and requested
start date) on the first page.
Write a Lay Summary that will be understandable to the general public. Indicate the value of the
research to human health or society, and include a brief description of procedures to be used on
animals. Respect the space limitations of the page.
Provide information on the animals to be used as requested. Only mice and rats can be housed in
the Animal Care Facility at this time. Invertebrates are not included in the responsibilities of
IACUC, and other mammals cannot be used at present in our facility. Provide information to justify
your use of the animal species you are proposing to study. Include reference search information to
demonstrate that the work is not simple duplication of prior work.
Describe the justification for the number of animals to be used. Include number of groups to be
studied, number of animals per group, and statistical analysis, if any, that will be performed as
it may justify the numbers requested.
Provide information as it obtains to wild animals if applicable. These animals cannot be housed
in the current facility.
Provide information on where the animals will be housed. Do not assume you can add them to the
Animal Care Facility without first checking on the current usage of the facility. Provide
information on whether animals will be removed from the facility for any significant period of time
and then returned to the facility, and how they will be cared for when not in the facility.
Explain any specific housing requirements, light cycles, type of feed or any other special
requirements, or simply check the field that indicates that standard care is adequate. (To check
the box, right-click on the box, select Properties, then Checked.)
Indicate whether procedures to be used will cause pain or distress, and the degree and duration
using the selections on the form.
Carefully read the responsibilities of the principal investigator that you are agreeing to abide
by for the duration of the research. If you do not abide by these requirements, your protocol may be
terminated without appeal.
Describe all chemical or biological agents that will be administered to the animals. This
includes alterations of diet and restriction of access to food and water. Routes of administration
and doses must be provided, including for agents used for euthanasia.
Describe all procedures to be performed on living animals in detail. Include names of all
persons who will perform these procedures. Make sure all persons named have adequate training
before they perform any procedures.
Sign and date the Investigator’s Assurance. Read it carefully as you will be bound by its
Submit it to the IACUC Committee for approval. You are not allowed to purchase animals or begin
experiments until you have a signed approval. Remember that approvals have time limits, and if the
research will extend beyond the Approval Period, you must file the forms to gain approval for the
next period. You may adapt the forms filed for the initial approval to fit your current
requirements, but do not simply change the date and resubmit exactly the same form, or the
committee may think you have done no work in the prior period and withhold approval on that
Contact the IACUC Committee Chair if you have any problems in filling out these forms.